A 130 nm CMOS integrated Lab-On-a-Chip based on DeFET sensor for biomedical analysis

This paper presents a new integrated Lab-On-a-Chip (LOC) based on Differential electric-field sensitive Field-Effect Transistor (DeFET) sensor array that is used in Biomedical Analysis. The proposed system introduces a 4 × 4 DeFET sensor array, analog multiplexer, and readout circuit that perform the sensing, actuating, and signal conditioning tasks. The proposed LOC is verified using circuit level simulation in the UMC 130 nm CMOS technology node. Results show that the sensitivity of the DeFET sensor is appreciably enhanced. The proposed LOC consumes 470 μA from 1.2 V supply with an input referred noise of 70 nV/√Ηz at 1MHz. The area of the proposed LOC equals to 0.9 mm
²
. Besides that, the physical stricture, the equivalent circuit, and the theory of operation of the DeFET sensor are discussed.