MISO GPC for blood glucose control in T1DM

In this paper, a new two-input one-output model, derived from Hovorka model - a famous SISO model of type-I diabetics-is proposed, with both the insulin and glucose as inputs. For the new model, a multiple GPC combined with a system identification system is also designed. This controller is used to regulate the B.G. level within the normal band in less than 2 hours after meal intake. It can handle the inherent time delays existed in the system dynamics. In comparison to the single-GPC used for Hovorka mode, the proposed procedure removes the need for the feed-forward controller. The new procedure can also regulate the blood glucose automatically and more accurately and prevent diabetics from hypoglycemia, a fatal phenomenon. The validation of the new procedure is shown via simulations and via the Clarke error grid analysis, an accepted clinical analysis.