Multi-analyte paper-analytical-devices (PAD) with CMOS integration for point-of-Care diagnostics

A three dimensional paper-based analytical device (PAD) with multiple electrochemical sensors, an integrated sample reservoir and tight integration with a custom CMOS potentiostat is presented. The sensors are fabricated using a combination of wax printing and screen printing using a solution based approach in ambient conditions without the need for expensive fabrication equipment or a cleanroom. Multiple working electrodes allow the sensor to be used for multiplexed multi-analyte measurements. Functionality is demonstrated with electrochemical measurements for the detection of dopamine and glucose. Together the 3D paper-based analytical device with integrated sensor microfluidics and custom CMOS potentiostat demonstrate a low-cost, self-contained system suitable for point-of-care diagnostic devices.