Embedded sensors for Micro Transdermal Interface Platforms (MicroTIPs)

Wearable `smart patches' of the future will incorporate microneedle technologies that painlessly interact with the body, using closed-loop theranostic systems to continuously monitor the physiological status of the body and deliver appropriate therapeutic agents when needed. Among other components, these Micro Transdermal Interface Platforms (MicroTIPs) will require embedded sensors to verify that the patch is operating as intended. In this paper, we integrate hollow microneedles with miniaturized pressure and impedance sensors to create an inline sensor subsystem suitable for integration with such a smart patch. Preliminary experimental work using an ex-vivo skin model shows that the sensors are capable of detecting microneedle skin insertion and removal, and of monitoring fluidic pressure and detecting leaks during the delivery phase.