The effect of the inhomogeneous magnetic fields on the antitumor activity of magnetic nanotherapy

In the research of animals with carcinosarcoma Walker-256 was shown, that magnetic nanocomplex on the basis of nanoparticles of Fe
₃
O
₄
with antitumor anthracycline row antibiotic doxorubicin and next local electromagnetic irradiation by spatially inhomogeneous constant magnetic and variable electromagnetic fields had nonlinear effect on growth tumor volume in the direction of strengthening and inhibition tumor size. The radio frequency mild hyperthermia and magneto-sensitive nanocomplex increased antitumor effect up to 16% as compared to conventional doxorubicin.