Orthogonal-polarimetric differential tilted fiber grating biosensor

High sensitivity biological sample measurement has been achieved by using a 12° tilted fiber Bragg grating (TFBG). Human acute leukemia cells with different intracellular densities whose refraction index (RI) ranging from 1.3342 to 1.3344 were clearly discriminated by using the differential spectral measurement of the cutoff resonance between two orthogonal polarizations, combining with a temperature self-calibration property.