Challenges in recording and stimulation of living neural network based on original micro-electrode array (MEA) developments

Recent research in micro-manufacturing together with new technologies in bioelectronics can lead to neuroscience applications to explore the properties of neural networks. Micro Electrode Arrays correspond to a well suited tool to either stimulate or record large populations of cultured cells and tissues. Based on existing state-of-the-art MEAs, the paper describes original developments to improve either recording or stimulation of neural networks, focusing on action potential discrimination.