The intervention experiment study of diabetic deaf animal model by Jiangtang Fanglong capsule

We discussed the influence of Jiangtang Fanglong capsule (glucose-lowering deaf-preventing capsule) to hearing of experimental diabetic deaf animal model. The experimental diabetic deaf animal model was replicated by disposable intraperitoneal injection of 55mg/kg streptozotocin(STZ) to every Wistar rats. 40 Wistar rats were randomly divided into two groups, treatment group treated by 10g•kg-1•d-1 Jiangtang Fanglong capsule suspension in intragastric gavage, and control group by equivalent normal saline, the two groups were separately accepted auditory brainstem response(ABR) detection in first month,second month,third month after model establishment. After first month, the latency and inter period of each wave of ABR of two groups were no significantly difference(P>0.05);and after second, third month, the latency and inter period of each wave of ABR of treatment group were obviously shorter than that of control group, difference was significant(P<0.05, P<0.01). Our results suggest that Jiangtang Fanglong capsule may be have a prevention and cure function to the hearing of diabetic deaf animal model.