Single-metabolite Bio-Nano-Sensors and system for remote monitoring in animal models

A novel system for remote monitoring of metabolism in animal model is proposed in this paper. The system is obtained by integrating Bio-Nano-Sensors to detect single-metabolites, an electrochemical front-end made with off-the-shelf components, an RF communication sub-system, and an antenna of new design. The system has been calibrated and tested for continuous monitoring of four different metabolites: glucose, lactate, glutamate, and adenosine triphosphate (ATP). Tests with animal models (mice) have been conducted to investigate tissue inflammation induced by the implanted Bio-Nano-Sensors. The tests confirmed that our system is suitable and reliable for remote monitoring of single-metabolites in experiments with animal models.