A 16 × 16 multi-electrode array with integrated CMOS amplifiers for neural signal recording

This paper reports on an active 16 × 16, low-noise, low-power, multi-electrode array (MEA) neural sensor chip designed in IBM BiCMOS 8HP 0.13 μm process with a total gain of 60 dB per input, a 20 kHz sample rate, an input-referred noise of 5.3 μVrms over 10 Hz to 10 kHz and a total power dissipation of 15.8 mW, or 61.7 μW per channel. A C4 microelectrode is attached to the input of each amplifier forming a multi-electrode array with 200 μm pitch for extracellular neural recording.