Influence of hot embossed process parameters on biodegradable polymer microstructure for drug delivery

Based on UV-LIGA technology and the hot embossing method, a novel controlled drug delivery micro-system is proposed in this paper, which is made by biodegradable polymer and suitable for subcutaneous implant releasing drug targeted. The fabricating processes about using molds and the microstructure are introduced, and then, experiments are conducted to investigate the influence of the embossing time, the pressing force and the hot embossing temperature on the quality of micro-structural formation. By the orthogonal test and analysis, the above parameters are optimized and the optimum parameters are: the hot embossing temperature at 90°C, the pressing force of 25N and the hot embossing time of 180s.