Silicon nanowires for high-sensitivity CRP detection

Silicon nanowires (SiNWs) were fabricated as supporting matrices for C-reactive protein (CRP) immobilization to construct CRP quantification biosensor. Anti CRP was immobilized onto SiNWs after chemical treatments such as aldehyde or carboxyl functionalized at the surface of SiNWs. Patients' sera were systematically collected to monitor the changes of currents according to CRP concentration. For the detection of CRP, SiNWs showed a linear response and their corresponding signal changes were reported and CRP levels were measured beforehand by clinical diagnosis tools used in hospital for clinical examination.