Frequency-domain analysis for intron prediction

It has been shown that gene-coding regions exhibit a strong 3 base-pair (bp) periodicity. As a result of this property, the gene-coding regions within a DNA sequence may be predicted by performing a frequency-domain analysis of the sequence. Developing on this concept, a second periodicity known to be present in DNA sequences is on average equal to 10.4hp, and this corresponds to the helical periodicity or the number of bases in a complete turn of the double helix. The frequency-domain analysis was expanded to examine for the helical periodicity in order to predict regions that are not responsible for gene-coding.