Application of multi-centrality in human metabolism

Lots of studies have focused on the structure and function of high-quality human metabolic networks. Recently, hub-based centrality is used to analysis of human metabolic network core. However, it is clear that this specific centrality measure is not sufficient alone. In the present paper, by comparing 10 different centrality measures with their application to human metabolic network core, be similar but smart, we give the top 10 center metabolites in the core, and discuss their biological and curatorial signification.