Polyacrylic acid-derivatized superparamagnetic iron oxide nanoparticles for delivery of tissue plasminogen activator

Polyacrylic acid (PAA)-derivatized Fe3O4 magnetic nanoparticle (MNP) intended as a drug carrier were synthesized by two different approaches and studied for chemicophysical properties. PAA-MNP prepared by physical adsorption of PAA on pre-formed MNP showed better properties for covalent binding with a thrombolytic drug, recombinant tissue plasminogen activator (rtPA). The PAA-MNP-rtPA conjugate showed full retention of thrombolytic activity and is useful as a magnetically targeted drug carrier to improve clinical thrombolytic therapy.