Six-channel neural signal regeneration integrated circuit

A six-channel neural signal regeneration integrated circuit (IC) was designed and fabricated in CSMC's 0.5-mum CMOS technology. The circuit consists of a low-noise and high common mode rejection ratio (CMRR) instrument amplifier, an inverted operational amplifier (OPA) and a buffer. The six-channel IC occupies a die area of 1.9 mm x 1.6 mm. The testing result shows that the consumption of a single channel is less than 5 mW, and the output voltage swing reaches 5 V under plusmn 2.5 V power supply, the gain can be adjusted from 60 dB to 110 dB. The circuit has been used for in-vivo experiments on toad's nerve with electrodes to regenerate neural signals. Different neural signals have been successfully regenerated on toad's nerve and corresponding actions have been observed.