Highly distorted urea based channel lattice complexes as an alternative to solid dispersions for improving content uniformity and dissolution rate

Normally nonadductible endocytic drugs (NNAED) such as vitamin E and famotidine were successfully included in urea in the presence of a rapidly adductible endocyte (RAE). Formation of urea based conclusion compounds of vitamin E and famotidine was confirmed by IR spectroscopy, DTA, polycrystalline X-ray diffraction and calorimetric analysis. Weakening of the hexagonal lattice of host urea owing to distortion caused by the presence of highly substituted NNAED was exploited for the enhancement of dissolution rate of famotidine and vitamin E. The simultaneous accomplishment of improved content uniformity and an enhanced dissolution rate, due to ease in dispersion of the drug at a molecular level offer this technique a vast potential as an alternative to conventional solid dispersions.