Histotripsy for the treatment of BPH: evaluation in a chronic canine model

Histotripsy was evaluated as a non-invasive BPH treatment. The prostates of 20 canine subjects were targeted with one of three histotripsy doses. Prostates were harvested immediately, 7 days, or 28 days after treatment and assessed for changes. Lower treatment doses were found to produced scattered cellular disruption and hemorrhage that was sometimes reversible. Higher doses perforated the urethra and produced cavities in the glandular prostate that healed to leave an enlarged urinary channel.