Design of a Novel Acid-Sensing Biosensor Based on Taste Neurons and LAPS

A novel biosensor based on the platform of neuron- silicon interface was designed and characterized. Taste receptor cells cultured on light addressable potentiometric sensor (LAPS) can recognize sour stimuli as compared with non-acid solutions. A computational model of taste receptor cells was constructed to simulate the ionic currents and action potentials of taste receptor cells, to help decode extracellular signals recorded by LAPS. This study provides the prototype of a novel biosensor which deploys the sensory transduction and decoding mechanism from biology to realize chemosensing, potentially in a noninvasive and long- term manner.