Fabrication and Characterization of Electrospun Poly(L-Lactic Acid)and Poly(L-Lactide-Co-Glycolide) Mats as Wound Dressing

Electrospun poly (L-lactic acid) (PLLA) and poly (L-lactide -co -glycolide) (PLGA) mats were fabricated as wound dressings. The in vitro degradation behavior was studied in phosphate buffer solution (PBS, pH 7.4) at 37degC for 6 days. Structural and morphological changes during degradation were investigated with gel permeation chromatography (GPC) and scanning electron microscopy (SEM). Both of the electrospun biopolymer mats showed stable degradation rate without losing the fibrous structure. Water adsorption ability, water retention ability and water vapor permeability were monitored comparing with PLGA casting film. The results indicates that the electrospun PLLA and PLGA mats are suitable for wound dressing and PLGA mat is more preferable.