Effects of Puerarin on Monoamino Neurotransmitter Levels in the Striatum of Cerebral Ischemia Rats

This study was undertaken to examine the patterns of changes in extracellular fluid (ECF) dopamine (DA), orepinephrine (NE) and serotonin (5-HT) in the striatum of rats with middle cerebral artery occlusion (MCAO). The effect of Puerarin on monoamine neurotransmitter in the MCAO rats was also studied. Methods: Microdialysis was used to sample the brains extracellular space during 80 min of cerebral ischemia followed by 80 min of reperfusion. The microdialysate was measured by high performed liquid chromatography (HPLC). Results: It showed Puerarin could alleviate cerebral ischemia damage.