A Dynamical Model on the Network of p53-Mdm2 Feedback Loop Regulated by p14/19ARF

Base on new experimental results, we give a dynamical model to study the dynamical mechanism of the negative feedback loop composed of p53 and Mdm2 proteins regulated by p14/19ARR The oscillatory behaviors for the activities of p53 and Mdm2 proteins regulated by p14/19ARF in individual of cells are described in our dynamical model. The results help us build a basal network about oscillatory behaviors among p53, Mdm2 and P14/19ARR The dynamical model and its numerical results will help us understand the oscillatory behavior among other network of different proteins.