Modeling and Optimization of Assisted Circulation

Many methods of mechanical assistance to aid the failing heart have been, and are being, extensively investigated. The hemodynamic goals of the different methods being studied vary depending upon the specific patient problems, however, they all fit into three general categories: decreasing the work of the failing myocardium by reducing the load on the left ventricle; increasing blood flow through the coronary circulation, and consequently increasing the oxygen supply to the hypoxic tissue; and increasing cardiac output, and thus increasing the blood supply to the peripheral organs.