A computer simulation of the dynamic interaction between regional coronary flow and LV mechanics

A model was developed to study the time-varying relation between regional LV mechanics, local coronary flow and some of the important underlying metabolic factors. The authors' previous LV model was extended to simulate the changes in regional behavior of the heart imposed by modifications in local coronary flow. This was accomplished by quantifying the relation between regional heart metabolism and function. The resulting model is capable of predicting the acute changes in heart function during the development of myocardial ischemia following coronary stenosis.<>