Novel Microarray Technology for Post-Genomic Studies

There are great challenges of developing high-throughput analytic tools in the post-genomic era. The microarray technology, as one of the most poowerful high-throughput tools, has a lot of opportunities in meeting increasing enormous demands in the discovery of the molecular mechanisms of life systems. A number of the new concept microarrays will be developed and used in fundamental and medical researches in the near future. We developed several kinds of the new microarray chips for detecting DNA methylation patterns, double strands DNA microarray for sequence-specific DNA binding proteins (such as transcription factors), the PCR procduct microarray for screening disease related SNPs, a cap-array assay (lab-in-a-tube system), and quantitative detection microarray for mulit-viruses detection and clinical applications. In this presentation, I will give brief introductions on these biochip platforms developed in our laboratory recently. Our results show that the innovations in high-throughput tools could be promoted through the combination between life science and engineering researches.