A role of sphingomyelin lipid circle components in inflammation process caused by CCl/sub 4/ at rats liposomes loaded by sphingomyelin or ceramide administered

Sphingolipids comprise indispensable structural components of all known eukaryotic plasma membranes they regulate the signal transduction elements including protein kinase C. Sphingosine, ceramide and other sphingolipid derivatives are also known to play central role in apoptosis, cell cycle regulation, inflammation and intracellular calcium mobilization. To get experimental inflammation of a rat liver the CCl/sub 4/ was administered. During the process of experimental hepatitis development the liposomes loaded by the modulators of a sphingomyelin lipid cycle (SLC) - the sphingomyelin and ceramide were administered. The components of a SLC change were tested by the contents of a sphingomyelin, ceramides. The increase in ceramides and decrease in spingomyelin contents at the rat's liver was revealed. Thus a result indicates the decrease in an inflammation process of a liver tissue. The morphological research of a liver tissue confirmed the reduction of hepatitis activity during the liposomes entered. The injects of liposomes loaded the SLC's modulators reduced the activity the inflammation process of liver tissue.