Optimizing inhalable nanoparticles

The aim of this study was to develop a new system of carrier particles and to optimize their Mass Median Aerodynamic Diameter (MMAD). We investigated different formulations and synthesized a new type of carrier particle, which releases nanoparticles actively. The active release mechanism of the nanoparticles from the carrier particles was achieved using sodium carbonate together with citric acid in a water solution. The MMAD of these formulations ranged from 2.8 to 3.60 /spl mu/m. This study shows that it is possible to produce carrier particles loaded with nanoparticles with an appropriate MMAD to reach the deep area of the lungs.