Nanoimprint - a tool for realizing nano-bio research

In this paper, we present a status report on how implementation of nanoimprint lithography has advanced our research. Contact guidance nerve growth experiments have so far primarily been done on micrometer-structured surfaces. We have made a stamp with 17 areas of different, submicron, line width and spacing covering a total 2.6 mm/spl times/0.45 mm. This has been imprinted, in PMMA, and consequently used in experiments to investigate how axonal outgrowth is affected by the nanopatterns. Protein interactions with nanostructured surfaces are also studied in a system exploring and controlling biomolecular motors, i.e., the muscle motor proteins actin and myosin.