Tumor State-Space Network for High and Low Grade Glioma Classification

Accurately predicting the grade of gliomas is crucial for choosing right treatment plans. While current methods using radiomics and deep learning can predict glioma grades effectively using magnetic resonance imaging (MRI), they overlook dynamic changes in the tumor and its neighboring areas. To address this issue, we propose a tumor state-space network (TSSNet), which fully exploits changes in the tumor region and its surroundings through dynamical updating strategy. The experimental results demonstrated that TSSNet achieves 90.32% accuracy and 93.55% area under the curve (AUC) for the prediction of high-grade and low-grade gliomas, respectively, which are 2.4% and 2.5% higher than the best state-of-the-art deep learning models. Moreover, the proposed state-space module can effectively enhance prediction performance, which is advantageous for personalized glioma treatment.