3D-CBS: Features, Implementation and Usage Targeted to Reduce More than 50 percent of Premature Cancer Deaths and Costs

Background - 3D-CBS (3-D Complete Body Screening): first true paradigm change in biomedical imaging invented 23 years ago, confirmed by third party measured results on a 3D-CBS copy as able to safely detect clusters (tumors) of 100 cancer cells instead of millions of cells. Materials and methods - 157 cm -FOV 3D-CBS capable of detecting all possible 511 keV -pairs of photons from the tumor markers at the lowest cost/valid pair captured, with components costing less than ${\$}$2,000,000/device, ${\$}$200/2-minute screening test, and ${\$}$1,200/15-minute clinical exam, in two 8 -hour shifts can safely perform 360x2-minute tests, 8x15-minute exams. It is estimated 48 professionals/day are needed: 8 administrators, 4 logicians, 8 nurses, 8 technologists and 20 doctors; each doctor reading 16-20 screening tests/day for 22 minutes each, and 1 clinical exam for 68 minutes. People must perform several screening tests on the same machine, using the same protocol and radiation dose. To avoid false positives, the diagnosis will not be based on a single screening test but on the Total-Body Computer-Aided Diagnosis (TB-CAD) tool calculating the trend of anomalies in several screening tests and radiologists’ experience. Several screenings tests reveal unique hotspots showing increased activity/size of an anomalous biological process requiring deeper investigation (15-minute clinical examination). Screening tests before/after surgery detect if any cancer cells have been left over and monitor for recurrences at an early curable stage. Results - 90,000/test/year/device, 57billion tests/30-year on 57,000x3D-CBS devices built gradually over 30 years can save over 100,000,000 lives and over ${\$}$27 trillion. Conclusions - Because early cancer detection can save up to $98 \%$ lives, an experimental test on a sample population using this approach based on the TB-CAD trend calculated over several 3D-CBS screening tests will prove definitively that we can save millions of lives and trillions of dollars