Optical fiber biosensors based on surface plasmon resonance effect: A Review

Optical fiber surface plasmon resonance (SPR) biosensors have great potential in the early-stage detection of diseases, owing to their advantages of fast detection speed, high specificity, high sensitivity, and convenient operation. Through microstructure processing of bare fibers, make the evanescent wave as much as possible exposed to dielectric layer, the coupling between the evanescent waves and plasma waves can be increased, or by improving optical fiber sensing area metal film structure or the introduction of new materials, enhance the intensity of the local electric field around the sensing layer, lead to stronger light and material interactions, all of which can improve the sensitivity of the optical fiber surface plasma resonance sensor. This article succinctly elucidates the sensitivity mechanism of plasma resonance biosensors and outlines the latest research progress in cancer, infectious diseases, and inflammation.