Advancing Hematopoietic Stem Cell Transplantation Typing: Harnessing Hyperledger Fabric’s Blockchain Architecture

Hematopoietic stem cell transplantation (HSCT) is a crucial treatment option for hematological disorders. This study aims to design and develop a blockchain-based system tailored explicitly for HSCT typing and evaluate its performance and capabilities. The system, built on Hyperledger Fabric 2.4.6 and integrated with LevelDB and MySQL databases, implements features such as data on-chaining, access control, information retrieval, and matching through chaincode. It ensures accurate and efficient human leukocyte antigen (HLA) typing while protecting patient and hospital data security. Tests demonstrate the system’s ability to safeguard data security and reliability effectively. Performance metrics, including block size, CPU utilization, network throughput, and response latency, were evaluated on Ubuntu 20.04.2 operating systems using VMware Workstation 16 Pro and Docker containerization. By leveraging blockchain’s traceability and immutability, the system achieves data security, reliability, and verifiability, enabling faster and more accurate typing and improved healthcare efficiency. This innovative approach optimizes user experience, maintains data integrity, and ensures privacy. Future integration with existing databases could enable secure data sharing among healthcare institutions, allowing rapid verification of data ownership and unified authentication. This study contributes a significant advancement in hematologic disease treatment and research, offering practical implications for improving HSCT processes.