Gender Based Analysis of Insulin Like Growth Factor-1 (IFG-1) and Prevalence of Osteoporosis in South Indian Population

IGF-1 plays a pivotal role in promoting cell proliferation and growth, making it a key factor in growth-related diseases such as osteoporosis and diabetes. Serum IGF-1 levels can contribute to abnormal growth patterns, underscoring its significance in the pathophysiology of these conditions. Gender-based IGF-1 analysis is crucial for understanding and addressing variations in insulin-like growth factor-1 levels between men and women, providing valuable insights into potential gender-specific health implications and optimizing personalized healthcare interventions. The present study focuses gender based analysis in south Indian population because race is also one of the important factor in IGF 1 level. In this study, 195 blood samples have been collected from male and female volunteers and their IGF 1 value were quantified using systematic biochemical procedure with the help of ELIZA reader. Age-related analysis showed that IGF levels decrease with older age in both men and women. Women have significantly lower IGF 1 levels than men
$(\mathbf{p} < \mathbf{0.05})$
. Especially during menopause, the IGF-1 levels of women decrease significantly. The bone mineral density T-score is low and showed greater correlation with IGF-1 level in female than male, which may be the reason for the high incidence of osteoporosis in women. However, further studies with different severities of osteoporosis are needed.