Optimization of Physical Dimensions of Mach Zehnder Interferometer for Biosensing Application

This work presents the design aspects of Mach Zehnder Interferometer (MZI) based biosensors for bio-molecular detection. The effects of physical dimensions in the wave propagation in a Mach Zehnder Interferometer (MZI) has been studied using Comsol Multiphysics software. The design is proposed for development of biosensor for detection of lipoarabinomannan (LAM) antigen. The MZI structure has been realized using Y-junctions with s-bend configuration and cut-off bend radius is determined. This study is required for nanoscale fabrication and to achieve high sensitivity in biosensing application especially in detection of TB in early stages through urine samples.