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Proceedings of the IEEE

Issue 4 • April 2006

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Displaying Results 1 - 21 of 21
  • [Front cover]

    Publication Year: 2006, Page(s): c1
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  • Put your technology leadership in writing

    Publication Year: 2006, Page(s): c2
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  • Table of contents

    Publication Year: 2006, Page(s): 669
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  • Proceedings of the IEEE publication information

    Publication Year: 2006, Page(s): 670
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  • Special Issue on The Physiome and Beyond

    Publication Year: 2006, Page(s):671 - 677
    Cited by:  Papers (5)
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  • Modeling Human Physiology: The IUPS/EMBS Physiome Project

    Publication Year: 2006, Page(s):678 - 691
    Cited by:  Papers (18)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (784 KB) | HTML iconHTML

    The Physiome Project is an international collaboration to provide a framework for understanding human physiology, from proteins and cells to tissues and organs, with multiscale models that use computational techniques derived from engineering and software approaches from computer science. With the increasing interest in modeling living systems from research scientists in many branches of mathemati... View full abstract»

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  • Channeling the Data Flood: Handling Large-Scale Biomolecular Measurements in Silico

    Publication Year: 2006, Page(s):692 - 709
    Cited by:  Papers (2)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (380 KB) | HTML iconHTML

    The cells of the human body each contain thousands of molecular species,the dynamic interactions of which constitute the biomolecular system underlying cellular function. Many thousands of expressed genes, proteins, and metabolites can be measured simultaneously in a tissue or blood sample, making a scan of most biomolecules possible. This wealth of information causes the bottleneck in biomedical ... View full abstract»

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  • Mechanical Instabilities as a Central Issue for InSilico Analysis of Cell Dynamics

    Publication Year: 2006, Page(s):710 - 724
    Cited by:  Papers (6)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (1865 KB) | HTML iconHTML

    Even if the leading role of mechanical forces in tissue growth and remodeling is well admitted, it is only recently that the effects of physical forces on gene expression and cell dynamics have been more extensively investigated. In this multiscale context, developing in silico models of cells and tissues is necessary to understand how biochemical and biomechanical cell signaling pathways interpla... View full abstract»

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  • Biomechanics Modeling of the Musculoskeletal Apparatus: Status and Key Issues

    Publication Year: 2006, Page(s):725 - 739
    Cited by:  Papers (20)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (1765 KB) | HTML iconHTML

    The aim of this review paper is to report on the current state of the art in creating in silico humans able to simulate the biomechanics of the human body at all scales of interest. The focus is on the musculoskeletal apparatus, although much of what is written is valid also for the biomechanical modeling of other organs. The state of the art of computational biomechanics at body, organ, tissue, a... View full abstract»

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  • Kidney Modeling: Status and Perspectives

    Publication Year: 2006, Page(s):740 - 752
    Cited by:  Papers (15)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (950 KB) | HTML iconHTML

    Mathematical models have played an essential role in elucidating various functions of the kidney, including the mechanism by which the avian and mammalian kidney can produce a urine that is more concentrated than blood plasma, quasi-isosmotic reabsorption along the proximal tubule, and the control and regulation of glomerular filtration by the myogenic and tubuloglomerular feedback mechanisms. Thi... View full abstract»

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  • Lung Circulation Modeling: Status and Prospect

    Publication Year: 2006, Page(s):753 - 768
    Cited by:  Papers (2)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (959 KB) | HTML iconHTML

    Mathematical modeling has been used to interpret anatomical and physiological data obtained from metabolic and hemodynamic studies aimed at investigating structure-function relationships in the vasculature of the lung, and how these relationships are affected by lung injury and disease. The indicator dilution method was used to study the activity of redox processes within the lung. A steady-state ... View full abstract»

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  • Computational Methods for Cardiac Electromechanics

    Publication Year: 2006, Page(s):769 - 783
    Cited by:  Papers (46)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (767 KB) | HTML iconHTML

    Computational modeling provides a potentially powerful way to integrate structural properties measured in vitro to physiological functions measured in vivo. Focusing on the various scales (cell-tissue-organ-system), we give an overview of the importance and applications of numerical models of ventricular anatomy, electrophysiology, mechanics, and circulatory models. The integration of these models... View full abstract»

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  • Some Insights Into Computational Models of (Patho)physiological Brain Activity

    Publication Year: 2006, Page(s):784 - 804
    Cited by:  Papers (27)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (1357 KB) | HTML iconHTML

    The amount of experimental data concerning physiology and anatomy of the nervous system is growing very fast, challenging our capacity to make comprehensive syntheses of the plethora of data available. Computer models of neuronal networks provide useful tools to construct such syntheses. They can be used to interpret experimental data, generate experimentally testable predictions, and formulate ne... View full abstract»

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  • Implicit and Explicit Model-Based Signal Processing for the Analysis of Short-Term Cardiovascular Interactions

    Publication Year: 2006, Page(s):805 - 818
    Cited by:  Papers (14)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (546 KB) | HTML iconHTML

    The paper stresses the importance of model-based signal processing in the analysis of the cardiovascular regulation mechanisms. It is remarked that even traditional signal processing implicitly assumes a model and interprets data according to it. Therefore, traditional signal processing is here referred to as implicit model-based signal processing in contrast with explicit model-based signal proce... View full abstract»

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  • Strategies and Tactics in Multiscale Modeling of Cell-to-Organ Systems

    Publication Year: 2006, Page(s):819 - 831
    Cited by:  Papers (14)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (392 KB) | HTML iconHTML

    Modeling is essential to integrating knowledge of human physiology. Comprehensive self-consistent descriptions expressed in quantitative mathematical form define working hypotheses in testable and reproducible form, and though such models are always "wrong" in the sense of being incomplete or partly incorrect, they provide a means of understanding a system and improving that understanding. Physiol... View full abstract»

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  • Advanced Methods and Algorithms for Biological Networks Analysis

    Publication Year: 2006, Page(s):832 - 853
    Cited by:  Papers (32)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (899 KB) | HTML iconHTML

    Modeling and analysis of complex biological networks presents a number of mathematical challenges. For the models to be useful from a biological standpoint, they must be systematically compared with data. Robustness is a key to biological understanding and proper feedback to guide experiments,including both the deterministic stability and performance properties of models in the presence of paramet... View full abstract»

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  • Electrical Engineering Hall of Fame: Cummings C. Chesney

    Publication Year: 2006, Page(s):854 - 856
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (1454 KB) | HTML iconHTML

    In 1921, the American Institute of Electrical Engineers (AIEE) selected Cummings C. Chesney as the recipient of the Edison Medal. He was cited for his contributions to early developments in alternating current transmission". He later served as president of the AIEE during 1926 and 1927. He was known for his pioneering work with high-voltage power transmission. View full abstract»

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  • Future Special Issues/Special Sections of the Proceedings

    Publication Year: 2006, Page(s):857 - 858
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  • Proceedings of the IEEE information for authors

    Publication Year: 2006, Page(s):859 - 860
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  • IEEE Member Digital Library [advertisement]

    Publication Year: 2006, Page(s): c3
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  • Celebrate the vitality of technology

    Publication Year: 2006, Page(s): c4
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Aims & Scope

The most highly-cited general interest journal in electrical engineering and computer science, the Proceedings is the best way to stay informed on an exemplary range of topics.

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Meet Our Editors

Editor-in-Chief
H. Joel Trussell
North Carolina State University