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IEEE Transactions on NanoBioscience

Issue 1 • March 2005

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Displaying Results 1 - 19 of 19
  • Table of contents

    Publication Year: 2005, Page(s): c1
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  • IEEE Transactions on NanoBioscience publication information

    Publication Year: 2005, Page(s): c2
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  • Guest Editorial Special Issue on Ion Channels—Bionanotubes

    Publication Year: 2005, Page(s):1 - 2
    Cited by:  Papers (1)
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  • Fifty years of progress in ion channel research

    Publication Year: 2005, Page(s):3 - 9
    Cited by:  Papers (19)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (221 KB) | HTML iconHTML

    Fifty years ago, ion channels were but a reasonable hypothesis. I outline some major steps in transforming this idea from a plausible description of the biological assemblies responsible for controlling passive ion transport across membranes to established fact. Important electrophysiological, biochemical, molecular biological, structural, and theoretical tools are discussed in the context of the ... View full abstract»

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  • Gramicidin channels

    Publication Year: 2005, Page(s):10 - 20
    Cited by:  Papers (65)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (610 KB) | HTML iconHTML

    Gramicidin channels are mini-proteins composed of two tryptophan-rich subunits. The conducting channels are formed by the transbilayer dimerization of nonconducting subunits, which are tied to the bilayer/solution interface through hydrogen bonds between the indole NH groups and the phospholipid backbone and water. The channel structure is known at atomic resolution and the channel's permeability ... View full abstract»

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  • Potassium channels

    Publication Year: 2005, Page(s):21 - 33
    Cited by:  Papers (14)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (418 KB) | HTML iconHTML

    Potassium channels are integral membrane proteins that selectively transport K+ across the cell membrane. They are present in all mammalian cells and have a wide variety of roles in both excitable and nonexcitable cells. The phenotypic diversity required to accomplish their various roles is created by differences in conductance, the timecourse and mechanisms of different gating events, ... View full abstract»

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  • Voltage-gated ion channels

    Publication Year: 2005, Page(s):34 - 48
    Cited by:  Papers (53)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (699 KB) | HTML iconHTML

    Voltage-dependent ion channels are membrane proteins that conduct ions at high rates regulated by the voltage across the membrane. They play a fundamental role in the generation and propagation of the nerve impulse and in cell homeostasis. The voltage sensor is a region of the protein bearing charged amino acids that relocate upon changes in the membrane electric field. The movement of the sensor ... View full abstract»

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  • Unique structure and function of chloride transporting CLC proteins

    Publication Year: 2005, Page(s):49 - 57
    Cited by:  Papers (13)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (402 KB) | HTML iconHTML

    CLC proteins are a large structurally defined family of Cl- ion channels and H+/Cl- antiporters with nine distinct genes in mammals. The membrane-embedded part of CLC proteins bears no obvious similarity to any other class of membrane proteins, while the cytoplasmic C-terminus of most eukaryotic and some prokaryotic CLCs contains two regions with homology to cystat... View full abstract»

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  • Voltage-gated sodium and calcium channels in nerve, muscle, and heart

    Publication Year: 2005, Page(s):58 - 69
    Cited by:  Papers (11)  |  Patents (2)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (416 KB) | HTML iconHTML

    Voltage-gated ion channels are membrane proteins which underlie rapid electrical signals among neurons and the spread of excitation in skeletal muscle and heart. We outline some recent advances in the study of voltage-sensitive sodium and calcium channels. Investigations are providing insight into the changes in molecular conformation associated with open-closed gating of the channels, the mechani... View full abstract»

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  • Ligand-gated channels

    Publication Year: 2005, Page(s):70 - 80
    Cited by:  Papers (23)  |  Patents (4)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (779 KB) | HTML iconHTML

    Ligand-gated ion channels (LGICs) are fast-responding channels in which the receptor, which binds the activating molecule (the ligand), and the ion channel are part of the same nanomolecular protein complex. This paper will describe the properties and functions of the nicotinic acetylcholine LGIC superfamily, which plays a critical role in the fast chemical transmission of electrical signals betwe... View full abstract»

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  • Poisson-Nernst-Planck theory approach to the calculation of current through biological ion channels

    Publication Year: 2005, Page(s):81 - 93
    Cited by:  Papers (54)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (763 KB) | HTML iconHTML

    The Poisson-Nernst-Planck (PNP) theory of electro-diffusion is reviewed. Techniques for numerical solution of the three-dimensional PNP equations are summarized, and several illustrative applications to ion transport through protein channels are presented. Strengths and weaknesses of the theory are discussed, as well as attempts to improve it via increasingly realistic evaluation of the force acti... View full abstract»

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  • Semimicroscopic modeling of permeation energetics in ion channels

    Publication Year: 2005, Page(s):94 - 101
    Cited by:  Papers (2)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (246 KB) | HTML iconHTML

    The semimicroscopic (SMC) approach to modeling the energetics of ion permeation through biological channels provides an alternative perspective to standard molecular dynamics methods. It exploits the timescale separation between electronic and structural contributions to dielectric stabilization and accounts for electronic polarization by embedding the channel in a milieu that, on average, describ... View full abstract»

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  • Brownian dynamics Simulation for modeling ion permeation across bionanotubes

    Publication Year: 2005, Page(s):102 - 111
    Cited by:  Papers (8)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (435 KB) | HTML iconHTML

    The principles underlying Brownian dynamics (BD), its statistical consistency, and algorithms for practical implementation are outlined here. The ability to compute current flow across ion channels confers a distinct advantage to BD simulations compared to other simulation techniques. Thus, two obvious applications of BD ion channels are in calculation of the current-voltage and current-concentrat... View full abstract»

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  • Molecular dynamics Simulation approaches to K channels: conformational flexibility and physiological function

    Publication Year: 2005, Page(s):112 - 120
    Cited by:  Papers (14)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (736 KB) | HTML iconHTML

    Molecular modeling and simulations enable extrapolation for the structure of bacterial potassium channels to the function of their mammalian homologues. Molecular dynamics simulations have revealed the concerted single-file motion of potassium ions and water molecules through the selectivity filter of K channels and the role of filter flexibility in ion permeation and in "fast gating." Principal c... View full abstract»

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  • Microchip technology in ion-channel research

    Publication Year: 2005, Page(s):121 - 127
    Cited by:  Papers (63)  |  Patents (5)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (593 KB) | HTML iconHTML

    The electrical activity of living cells can be monitored in various ways, but for the study of ion channels and the drugs that affect them, the patch-clamp techniques are the most sensitive. Recent developments in microfabricated patch-clamp electrodes are reviewed, and technical challenges for the future are discussed. View full abstract»

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  • 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

    Publication Year: 2005, Page(s):128 - 130
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  • IEEE copyright form

    Publication Year: 2005, Page(s):131 - 132
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  • IEEE Transactions on NanoBioscience Information for authors

    Publication Year: 2005, Page(s): c3
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  • Blank page [back cover]

    Publication Year: 2005, Page(s): c4
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Aims & Scope

The IEEE Transactions on NanoBioscience publishes basic and applied papers dealing both with engineering, physics, chemistry, modeling and computer science and with biology and medicine with respect to molecules, cells, tissues. The content of acceptable papers ranges from practical/clinical/environmental applications to formalized mathematical theory.

Full Aims & Scope

Meet Our Editors

Editor-in-Chief
Henry Hess
Department of Biomedical Engineering
Columbia University