Novel In Vitro and In Vivo Neural Interfaces: Normal and Accelerated Failure Assessment

The in vitro acute brain slice test bed offers the advantages of natural configurations and proportions of cells and tissues. As a function of time, electrode insertion activates signaling pathways in microglia, astrocytes, and neurons that result in biochemical changes that alter the biophysical characteristics of the tissue.Temperature- modulated acceleration, based onthe Arrhenius equation, is a common method to predict the lifetime of samples.