Discharge Patterns' Change of Hindmarsh-Rose Neurons under Slow Ramp Current Stimulation

The Hindmarsh-Rose neuron under different initial discharge patterns is stimulated by the slow ramp current; and the change of the neuron's discharge pattern is discussed by analyzing its membrane potential's interspike interval (ISI) distribution. Under the slow ramp current stimulation, the neuron's discharge pattern gradually changes into dynamic period 1 discharge pattern whose ISI drops off with the ramp's amplitude increasing; and slow adaptation current gradually increases according to the linear function with the ramp's amplitude increasing, which reflects the linear cumulation of intramembranous calcium ion. This investigation shows the mechanism of the amplitude of the slow stimulation current affecting the neuron's discharge patterns, and the neuron's discharge patterns can be adjusted and controlled by the amplitude of the slow stimulation current. This result is of far reaching importance to study the synchronization and encode of many neurons or neural network, and provides the theoretic basis for studying the mechanism of some nervous diseases such as epilepsy by the slow wave of EEG.