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Finding transcription factor binding sites in DNA sequences: a template based approach

Gunewardena, S.   Zhaolei Zhang  
Comput. Lab., Oxford Univ.;

This paper appears in: Statistical Signal Processing, 2005 IEEE/SP 13th Workshop on
Publication Date: 17-20 July 2005
On page(s): 990-995
ISBN: 0-7803-9403-8
INSPEC Accession Number: 9122935
Digital Object Identifier: 10.1109/SSP.2005.1628739
Current Version Published: 2006-05-08

Abstract
The short and highly degenerate nature of transcription factor (TF) binding sites makes their identification a challenging task. We propose a new method based on templates for identifying TF binding sites. Templates account for sequence structure and nucleotide polymorphisms present in TF binding sits providing them with a greater discriminatory capability to methods based on sequence homology

Index Terms
Inspec

Controlled Indexing
DNA  

Non-controlled Indexing
DNA sequences   nucleotide polymorphisms   sequence homology   template based approach   transcription factor   transcription factor binding sites  

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