Naturally occurring ribosome inactivating proteins might be key molecules against Covid-19

SARS-CoV-2 is a novel coronavirus with a major outbreak of unusual viral epidemic in Wuhan, China. To date, some certain vaccines have been approved by FDA so that spelling the end of pandemic globally but COVID-19 is still a global leading cause of death, with a descending rates. The existence of antiviral properties of ribosome inactivating proteins towards many human, animal and plant viruses are well-known for so many years. Ribosome inactivating proteins are naturally occurring substances and toxic N-glycosidase enzymes which depurinate both eukaryotic and prokaryotic rRNAs, hence arresting protein synthesis in the coarse of translation. Interestingly, some ribosome inactivating proteins can also remove the purine nucleotides from non-ribosomal RNAs. Undoubtly, removing the rRNA purine nucleotides effects the protein synthesis and therefore, triggers ribotoxic stress response that commences apoptosis. These proteins might similarly hamper specifically the viral circles in one and/or more points in their lifecycle. In present study, we have focused on naturally occurring ribosome inactivating proteins as promising agents for struggle against Covid-19 disease.