Altered regional homogeneity in encephalitis with LGI1 antibodies: A resting state fMRI

This paper studied the regional homogeneity (ReHo) in patients with anti-LGI1 encephalitis and normal controls based on the resting state fMRI data. We calculated the ReHo values of 14 anti-LGI1 encephalitis patients and 14 normal controls. Then the differences of the ReHo maps between the two groups were detected by conducting two- sample t-tests. We found that the patients had significantly lower ReHo values in the caudate, middle temporal gyrus (MTG) and superior temporal gyrus (STG) compared with the normal controls. Our findings suggested that the abnormal ReHo values in these regions could be responsible for impairments of memory, cognitive and motor dysfunction of anti-LGI1 encephalitis.