MEG High-frequency Oscillations (HFOs) Identification and 3D Reconstruction with MRI based on MEG Processor

Magnetoencephalography(MEG) is a functional, noninvasive technology for recording neuronal activity of human brain in real-time. MEG has been approved as an efficient and powerful functional detection method which has been used in clinical practices relate with epilepsy, depression, and other diseases that cannot be well-diagnosed by traditional structural methods, e.g., CT and MRI. By using MEG, very weak magnetic signals typically in the range of 10 femtotesla (fT)-1 picotesla (pT) that originate from electric currents flowing in neurons, can be recorded. Compared with scalp EEG, MEG provides much better spatial resolution. Meanwhile, MEG is a noninvasive technology for preoperative workup for epilepsy surgery, which means it may replace traditional invasive methods. As the development of high-sampling rate MEG systems as well as the discovery high-frequency oscillations (HFOs) in the brain, MEG is now typically digitally analyzed in very high-frequency range. Although MEG has been clinically used for two decades, it is not so widely-used as EEG. The lack of a powerful software platform is an important reason which hinders the development of MEG. A MEG-specific software, MEG processor, was released here. With the friendly graphical user interface (GUI) of MEG Processor, researcher can easily identify/mark HFOs and project the signal to MRI receiving a precise 3D reconstruction. We hope such a platform will help and encourage more clinicians to uncover the magnificent features of MEG.