Acoustically Excited Micro Mass Transport for Remotely Dose-Controlable Drug Releasing

Remotely activated drug release strategy with controllable dosage is the key factor of various targeting drug delivery methods as minimal invasive treatment. This article describes mass transport in liquid in microscale with a controllability of releasing amount, which is wirelessly excited by an external acoustic excitation. A liquid droplet (releasing agent, or drug in application) is trapped in the middle of a one-end open microtube which has a ratchet-structure on its inner wall. The droplet is trapped in the tube and neighbored by two gaseous air bubbles on both sides. In the presence of acoustic wave, the air bubbles oscillate and resonate. The air bubble near the tube opening segregates the liquid droplet into smaller ones and transport them on the ratchet-surface wall of the microtube. This mass transport occurs in both directions at similar rates: from the surrounding fluid to the trapped droplet and vice versa. As a result, the overall mass of droplet remains similar. Meanwhile, the other bubble positioned back in the tube sealing side enhances mixing between incoming mass from the surrounding and existing mass in the droplet. This mass transport is significant only when the inner wall of the tube has rachets. The exchanging mass between the surrounding and droplet is monotonically proportional to the excitation period, showing high controllability of mass transport. This mass transport phenomenon possibly provides a new mechanism of in vivo, on-demand, dose controllable drug delivery.