Seizure Mapping Using an Intracranial Implantable Ultrasound Device

Surgical epilepsy treatment remains a problem that low spatial resolution of about 1cm result to low cure rate of about 30%. The implanted high frequency ultrasound transducer, which can be incorporated with the subdural electrode array, is proposed here in order to provide high resolution 3D seizure mapping using ultrasound to guide the epilepsy surgery. The purpose of this study is to investigate the quantitative ultrasound technique in distinguishing between different blood concentrations, and validate the effectiveness of the technique in phantom experiment and animal experiment. The measured mean scatterer spacing of the 100% anticoagulated bovine blood is about 0.0315 mm.