Smart Biolayers on Solid Phase: Rational Design and Investigation by Spectral-Phase Interferometry

Smart biomolecular layers, which enable/forbid binding of molecules depending on the presence in the microenvironment of certain analytes or ligands, have been self-assembled on solid phase. The spectral-phase interferometry was used for rational design of such layers, allowed estimation of kinetic parameters of reactions and determining the sensitivity of the smart layers to concentration of the ligands.