Photoinactivation with novel porphyrin derivatives: An in vitro study on multi-drug resistant escherichia coli

In the study, it was aimed to investigate the bactericidal activity of antimicrobial photodynamic therapy (aPDT) performed on in-vitro conditions with novel cationic-porphyrin derivatives (CPDs) on multidrug resistant E. coli. In aPDT experiments performed with different concentrations of photosensitizer and different energy densities, 99.9999% or more decrease in bacterial survival was detected. aPDT carried out with CPDs at concentrations below the MIC values has the potential to display a strong antimicrobial activity against the MDR E coli clinical isolates.