Label-free guided mode resonance sensor for detection of glycated hemoglobin

This paper demonstrates the use of Guided Mode Resonance (GMR) optical sensor platform for detection of Glycated Hemoglobin (HbA1c) in human blood. HbA1c is an importance biomarker for monitoring a long-term glucose level in diabetes patients. Here, the sensing approach utilizes boronate affinity by modification of the GMR surface with 3-Aminophenylboronic acid (PBA). The sensing signal is then measured via a resonance shift in a reflection spectrum as the change of the refractive index on the sensor surface. In preliminary experiment, standard HbA1c samples with concentration covering the detection range (5% and 10 %) are used. The results show a good trend of resonance shift corresponding to amount of HbA1c.