Terahertz spectroscopic diagnosis and sub-wavelength imaging of Myelin Deficit monkey brain with chemometric techniques

Myelin Deficit of the central nervous system leads to several severe diseases in human, but lack definitive diagnostic test. In this work, we proposed and performed terahertz spectroscopy and sub-wavelength imaging combined with chemometric techniques to discriminate and evaluate the severity of myelin deficit in and rhesus monkey brains. We demonstrated THz imaging with sub-100 μm spatial resolution of brain tissues. And our spectroscopy results well match with pathological analysis, indicating that THz is a quick, powerful, evolving tool for identification and evaluation in preclinical animals and potentially in para-clinical biopsy of humans.