Effect of pore size of stationary phase on the separation performance of chip-based gas chromatography columns

Chip-based semi-packed gas chromatography (GC) columns coated with two kinds of mesoporous silica (MS) stationary phase have been explored and compared in this paper. For the first time, the influence of pore size of the stationary phase on the separation performance in a micro GC (μGC) column has been investigated. As has been demonstrated, full separation of heavy hydrocarbons (C
₅
-C
₁₀
) can be achieved in both columns. Moreover, compared with stationary phase of smaller pores, that of bigger ones leads to obviously increased retention time of C
₉
and C
₁₀
.