White matter injury in a newborn rat model analyzed with Resting-State Optical Imaging of Intrinsic Signals (rsOIS)

Using rsOIS (Resting-State Optical Imaging of Intrinsic Signals), we demonstrated a non-invasive approach to assess cerebral changes in response to inflammatory white matter injury. Surprisingly, lipopolysaccharide (LPS) exposure induced an increase in inter-hemispheric functional connectivity (fc); this may reflect a possible compensatory mechanism to overcome the effects of inflammatory insult.